. Beta 1-3D Glucan is recognized by cells in the immune system, and can modify your immune system responses. Diarrhea. Pycnogenol accelerates wound healing and reduces scar formation [Abstract]. ( 1) 2. Pycnogenol is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins . Taking pine bark extract also increases the blood . Side effects. The antibacterial activity was assessed indicating that the essential oil of pine bark, specifically the proanthocyanidins, were effective against P. aeruginosa, significantly inhibiting its growth. This ensures that there is a healthy flow of blood to and from the heart. Pine bark distill has been studied regarding its relationship to exercise performance, oxidative stress and excitement to torso that has been imposed by exercise. (1, 2). You should also avoid using pine bark extract without talking to your doctor first if you: You should also do additional research or talk to your doctor before taking pine bark extract if you also take: While pine bark extract is a natural supplement, it can have powerful effects on your health, both positive and negative. In the study, the placebo group had higher IgE antibodies to the birch allergen than those who took Pycnogenol during the allergy season [17]. Pine bark extract provides many benefits to the skin, including reducing the signs of aging. A study of 147 people found that pycnogenol (100 mg/day) may improve running, push-ups, and sit-ups endurance in recreational athletes over an 8-week training program. Ana received her MS in Pharmacy from the University of Belgrade. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. Our team aims to be not only thorough with its research, but also objective and unbiased. This article explains which supplements are believed to be safe during pregnancy and which ones you should avoid. Pine bark extract may be the perfect treatment since its an antioxidant dynamo. It can then lead to heart problems like stroke or heart attack. Andrographis is a medicinal herb used to treat many health conditions, such as the common cold, osteoarthritis, and ulcerative colitis. Vinpocetine is used to increase brain circulation, alertness, cognitive function, concentration, and memory, as well as to lower inflammation and oxidative stress.This article will explore vinpocetine's history, how it works, its potential benefits, and any possible safety issues . (2017). , Improves Symptoms Associated With Menopause, A number of women experience physical discomfort due to symptoms of menopause. Moreover, Pycnogenol group either reduced or discontinued the use of asthma drugs. This plant extract also shows promise in such far-flung conditions as traumatic brain injury 40,41, skin problems 37, pain syndromes 38,39, and even tinnitus . Researchers suggest it may boost sustained attention, memory, executive functions, mood, and reduce oxidative stress [19]. A 10 week clinical trial with 30 children shows that Pycnogenol may improve symptoms of Crohns disease. Research suggests that taking pycnogenol improves mental function and memory in both young adults and the elderly. from the bark of the French maritime pine tree. Lets begin with asthma. After taking a break for one to two weeks, they can start taking it again for several weeks. In one study, people with high blood pressure were examined to see how the supplement impacted their blood pressure. But what makes this miracle ingredient so amazing? Pycnogenol; Pycnogenol. Studies have also safely used Pycnogenol in children and during pregnancy. In the Pycnogenol-treated group, blood sugar levels were significantly lowered as compared to those not on Pycnogenol. Headaches. In 22 German heavy smokers, platelet aggregation was prevented by 500 mg of aspirin or 100 mg Pycnogenol. . 2005 - 2023 WebMD LLC. It also may increase the activity of genes that make collagen and hyaluronic acid in the body [64]. 10 Day Erection Delay Sex Pills. One way to add some extra flavor and nutrients to your day is by adding prune juice to your diet. Pycnogenol also treatment improved blood vessel function. So it . In the placebo group, the retinopathy worsened; whereas, in the Pycnogenol-treated group, there was no deterioration. Pycnogenol is a compound of natural chemicals. It also appeared to improve their attention span, visual motor skills, and concentration. Pine bark extract comes from the inner bark of the Pinus pinaster tree, most commonly found in Europe. Pycnogenol French maritime pine bark extract acts as a potent blend of antioxidants, it is a natural anti-inflammatory, stimulates generation of collagen and hyaluronic acid and help with natural dilation of blood vessels by supporting production of nitric oxide. Blood pressure is an important measure of how much blood is pumping from your heart to the rest of your body. Improve cardiovascular health. There were 88 in the control group and 81 in the Pycnogenol group. Lowers Blood Pressure. It has many health benefits, and may help protect against several chronic conditions. Optimal doses of pycnogenol have not been set for any condition. Pycnogenol is a patented extract of the French maritime pine bark (Pinus pinaster). However, its always a good idea to start with a low dose so you can monitor how your body responds. While much of this is positive, it will be a while before doctors routinely recommend this dietary supplement for these conditions. Studies have found that when taken along with an inhaler, Pycnogenol can reduce leukotrienes, helping to relieve lung inflammation and limit frequency of inhaler use., Many people develop osteoarthritis as they age. Pycnogenol is similar to grape seed extract and cocoa polyphenols as those are the three most common . Prunes and prune juice have many health benefits. A review was conducted of French maritimepine bark extract, specifically using the nutritional supplement Pycnogenol. It is standardized to contain 65-75% procyanidins, a class of polyphenols and flavonoids like those found in blueberries, wine, grape skin, citrus, and cocoa. Most anal fissures heal with home treatment after a few days or weeks. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. Pycnogenol is a substance taken from the pine bark of trees found in the southwest region of France. Pycnogenol may help with other conditions as well. One study found that Pycnogenol may reduce the activity of the inflammatory enzymes COX1 and COX2, similar to how NSAID drugs work. If you are thinking of taking Pycnogenol for a serious health condition like asthma or high blood pressure, check with your doctor., People who have autoimmune conditions like multiple sclerosis or lupus should talk to their doctor before trying Pycnogenol. Normalization of cardiovascular risk factors in peri-menopausal women with Pycnogenol [Abstract]. 1. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. A 2006 study found that children who took a daily pine bark extract supplement for four weeks had significantly lower levels of hyperactivity. PQQ (pyrroloquinoline quinone), also called methoxatin, is a vitamin-like compound that exists naturally in soil and a variety of foods, including spinach, kiwi, soybeans, and human breastmilk . Ginkgo biloba has been widely cultivated across the globe for a variety of uses, most of which are medicinal. We don't yet know what the best dose to use is, but studies have used two 50 mg Pycnogenol capsules per day. L-arginine is more effective when paired with L-citrulline or pycnogenol to combat erectile dysfunction and improve exercise performance. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. A randomized clinical trial of 30 people found that Pycnogenol (150 mg/day) may help heal vein ulcers from surgery and reduce swelling after 3 months of treatment [25]. While it may seem intimidating at first, counting macros is a common Erythritol is now one of the most popular natural zero-calorie sweeteners available. DOI: Chowdhury WK, et al. Enzogenol, a slightly different pine bark extract, improved cognitive function in a clinical trial of 42 older men after 5 weeks of supplementation [23]. Pycnogenol is considered safe when taken orally in a dose of 50 to 450 mg per day for one year. The outcome showed significant healing when compared to those subjects who were not given any drug or remedy, concluding that Pycnogenol may be an effective remedy for healing of surgery-related lesions. This bark extract has been around for about 450 years. Various studies, referenced at uofmhealth.org, have shown that a daily dosage of Pycnogenol . DOI: Gulati OP. However, a study of 24 adults with ADHD found that pycnogenol did not improve ADHD symptoms better than placebo. Pycnogenol (100 mg/day) improved menopausal symptoms and quality of life in a clinical trial of 35 women after 8 weeks [68]. Pycnogenol (200 mg/day) may reduce muscle cramps and pain according to a study of 66 healthy people, athletes, and those with venous problems after 4 weeks. 1. The following purported benefits of Pycnogenol are only supported by limited, low-quality clinical studies. Used early on, it may prevent eye damage and blindness from diabetes [34]. The Benefits of DIM. However, these studies appear to be methodologically sound and reliable, with no blatant errors in the study design and data collection. Pycnogenol (100 mg/day) given to 44 older healthy people with high oxidative stress improved cognitive function, attention, mental performance, and reduced oxidative stress after 12 months [21]. This key chemical, proanthocyanidin, is also found in high concentrations in apples, cranberries, coca, grapes, and red wine. In one trial of 77 people with type 2 diabetes, pycnogenol (100 mg/day) for 12 weeks lowered both blood sugar levels and HbA1c, a marker of long-term blood glucose levels [31]. Pycnogenol has been well-tolerated in most studies performed thus far. The usual recommended duration of treatment for topical application is 7 days for Pycnogenol cream and 6 weeks for Pycnogenol powder. If you are taking blood thinners, do not take pine bark extract or Pycnogenol unless approved by your doctor. Too much pressure signals that your heart might be working too hard. Along with the rest of the crew, he developed symptoms of vitamin-C deficiency. A 2011 study by Dr. G. Belcaro concluded, " Pycnogenol administration was effective for better control of signs and symptoms of allergic asthma and reduced the need for medication". Upset stomach. The 2012 study on the anti-aging benefits of Pycnogenol is commonly-cited by anti-aging supplement manufacturers. Millions are hospitalized each year for . The study participants symptoms started to return a month after they stopped taking pine bark extract. ", Journal of Medicinal Food: "Review on Sustained Relief of Osteoarthritis Symptoms with a Proprietary Extract from Pine Bark, Pycnogenol. Pycnogenol seems well-tolerated for use in adults for up to 6 months. Start with a low dose so you can be sure it doesnt cause any side effects. Research indicates that Pycnogenol provides an increase in endurance performance of trained athletes. Helps maintain high vitamin C and E blood levels for their antioxidant effects. Pycnogenol (150 mg/day) reduced pain in a study of 100 people with osteoarthritis after 3 months. Also, be sure to talk with your doctor first if you have an underlying medical condition or take other medications. 7. Forty-seven Japanese men with mild erectile dysfunction were given supplementation L-arginine and French maritime pine bark extract over a period of time. When pycnogenol cream was added to oral supplements in a small study of 18 people with vein ulcers, it helped ulcers heal more quickly [26]. Plus, it reduced total and LDL (bad) cholesterol. This makes it very hard to set a standard dose. Researchers suggest that it may epigenetically turn off genes responsible for joint damage (ADAMTS) as well as reduce inflammation enzymes (MMP3) and cytokines (IL 1-beta) [47, 48]. The most effective blood sugar-lowering dose was 200 mg/day higher doses had no further benefit [33]. This review noted that pine bark extract may also help with: In addition to its skin-healing properties, pine bark extract also shows promise for helping children manage ADHD symptoms. Research indicates that Pycnogenol provides an increase in survival performance of train athletes. But, as you know, going for the natural approach can make a huge difference in overall health. Pycnogenol significantly improved the heavy feeling as well as the swelling. This can cause pain, especially in areas of the body that are used repeatedly, like your hands, fingers, and knees. Possible side effects . Research into Pycnogenol has revealed some promising results in over 30 health conditions. Sort By. Infants and children may not be able to synthesize enough of it, but it is present in many protein-rich . nausea. According to the National Institutes of Health, its safe for adults to take 50 to 450 milligrams of pine bark extract daily for up to one year. As a skin cream, its safe to use for about seven days. Pain score in the Pycnogenol-treated group was reduced by 56%, as compared to 9.6% reduction in the placebo group. Chewing gum with Pycnogenol (2.5 mg/piece) for 4 weeks reduced bad breath and mouth bacteria in a trial of 22 people [57]. We do not aim to diagnose, treat, cure or prevent any illness or disease. Regulations set manufacturing standards for supplements, but that does not guarantee that they are safe or effective. (11, 12), While both eliminate pain, the pine bark extract is a far better choice. These benefits appeared to persist for some time even after stopping supplementation [72]. In a study of 20 postmenopausal women, 12 weeks of pycnogenol supplementation improved hydration and elasticity of the skin. Diabetic retinopathy is a type of eye injury caused by complications from diabetes. The staff there can often answer any questions you have and give you more information about specific brands. Pycnogenol may stimulate the immune system. Potential for allergy when taken orally or used on the skin. Low-dose Pycnogenol (30 mg/day) may reduce pain in pregnant women, particularly hip, joint, lower back, groin, and calf cramps in the third trimester [71]. DOI: Marini A, et al. New studies show Pycnogenol can prevent or reverse the oxidative damage that produces blood vessel disease 4, metabolic syndrome 20, diabetes 20,24, and neurodegenerative disorders 23,24. It also may help regenerate and maintain vitamin C and E levels while also potentially increasing nitric oxide levels, which may relax and protect blood vessels [1]. Can Pycnogenol help? In a double-blind, placebo-controlled, randomized, crossover study, 50 patients with erectile dysfunction (ED) were treated with either L-arginine plus Pycnogenol or placebo for a month. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. Ask your doctor for advice. Healthline Media does not provide medical advice, diagnosis, or treatment. A high number signals high blood pressure. 4. Your email address will not be published. Organika Pycnogenol 50mg 50 Tablets . Commonly called arthritis, osteoarthritis is caused when the cartilage on your joints begins to wear down. Various brands of pycnogenol are available. They include: We need more research to know for sure if pycnogenol helps treat these conditions. ", Mayo Clinic: High blood pressure (hypertension)., Panminerva Medica: "Pycnogenol improvements in asthma management. Skin irritation. A clinically studied blend of Pycnogenol and a special bilberry extract (called Mirtogenol ) has been shown to provide benefits for vision and eye health. This article reviews tongkat ali, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Align your health hacks with your genes for optimal health & cognitive function. The same ingredient can be found in grapeseed oil, the skin of peanuts and witch hazel bark. Pycnogenol seems well-tolerated for use in adults for up to 6 months. As I mentioned, pine bark extract is superior when it comes to antioxidants. Grape seed extract may be more beneficial for those who are obese. (2013). returned. 10 Ways to Control Blood Sugar without Medication, Pycnogenol (French Maritime Pine Bark Extract): 12 Benefits According to Studies, Reduces leaky blood vessels by making the wall proteins (collagen, elastin) more resistant to damage, Helps maintain high vitamin C and E blood levels for their antioxidant effects, Inhibits platelet aggregation like low-dose aspirin, Reduces hardening in the arteries by increasing nitric oxide production in blood vessels, leading to greater dilatation, Counteracts the damaging effects of ultraviolet radiation, Stimulates the immune system by boosting T and B cell functions, Protects brain cells from toxic chemicals. Known for its antioxidant properties, Pycnogenol offers a wide range of potential health benefits. This includes supporting healthy blood circulation, acting as a natural anti-inflammatory, helping to generate collagen and hyaluronic acid for improved skin health and aiding in the production of endothelial nitric oxide which helps to dilate blood . Pycnogenol has not been found to cause these issues however, it may take a little longer the feel the relief from pain than aspirin. Another group of men who took just l-arginine didnt improve [66]. Its true. Trees of this pine have been naturalized in Australia and New Zealand, where most Enzogenol is now made [7]. According to a large analysis, Pycnogenol may reduce osteoarthritis symptoms and pain short-term [45, 46]. There's good evidence that pycnogenol helps with eye damage caused by diabetes. Results failed to show any efficacy of Pycnogenol or methylphenidate when compared to placebo. Clearer skin, healthier hair there are a lot of claims about the health benefits of biotin. 4 Items . These antioxidants scavenge those damaging free radicals in an effort to eliminate them, ultimately preventing disease. Side Effects of Pycnogenol. Make sure to seek out the advice of your physician prior to using pine bark extract or the branded name, Pycnogenol. The crew fell extremely ill from scurvy, an extreme lack of vitamin C. Cartiers crew crossed paths with a Quebec Indian who encouraged them to drink a tea made from pine bark and needles. Pycnogenol has several benefits to your health and beauty. Almost 400 years later, Dr. Jacques Masquelier from France came across Cartiers account and started to look for the active ingredients from the bark of the tree. Pycnogenol has four main components that contribute to its benefits for men's health. Pycnogenol pine bark extracts contain a unique blend of flavonoids whose antioxidant action is over is 50 times more powerful than vitamin E, 20 times more powerful than vitamin C and 16 times more active than grapeseed extracts. SelfDecode does not treat, diagnose or cure any conditions, Diabetes-associated small blood vessel changes is the leading cause of diabetic ulcers. Symptoms of menopausal syndrome, also known as climacteric syndrome, include: hot flashes; chills; headache; and depression. It seems to lower blood pressure and improve blood flow to the legs. Due to its anti-inflammatory properties, luteolin is being researched as a potential complementary treatment for multiple . All rights reserved. A study of 30 women found that Pycnogenol (75 mg/day) may reduce the skin area affected by melasma as well as lower symptoms of fatigue, constipation, body pain, and anxiety [62]. In one clinical trial of 156 osteoarthritis patients, pycnogenol reduced pain, stiffness, swelling, and improved joint function after 3 months. ( 4) Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. Instead, use plain water to wipe yourself and then dry your bottom afterward. Regardless of what youre using it for, its best to start with the lowest possible dose. Interesting activities, new dishes in restaurants, specialty ingredients, explanations of some netizens questions, etc.Hu Xuan is even helping Fatty s company s tourism manager, managing with Vice President Du Meixin, such as arranging guests reasonably.By the way.Dad, I want to tell you something.I plan to invest in the hotels and entertainment centers in the . 2005-2023 Healthline Media a Red Ventures Company. This nerve affects our balance and hearing by sending signals to the brain. While OPCs found in this extract are mostly known for their antioxidant-producing benefits, these amazing compounds exude antibacterial, antiviral, anticarcinogenic, anti-aging, anti-inflammatory and anti-allergic properties. In a clinical trial of 116 women, Pycnogenol (60 mg/day) reduced menstrual pain and the need for additional painkillers, taken over 2 cycles. Some research suggests that procyanidins may have antioxidant and anti-inflammatory activity. Once youre sure that you dont have any negative reactions, you may be able to increase your dosage according to the label. However, it's always a good idea to start with a low dose so you can monitor how your body responds. Note that each number in parentheses [1, 2, 3, etc.] It is chronic venous insufficiency, a common disease among people who are obese or elderly and those who lead a sedentary lifestyle. Lower the risk of Alzheimer's disease. A 2017 review reported on the many benefits of using pine bark extract to reduce the effects of aging on skin. but is for informational and educational purposes alone. For poor circulation: 45360 milligrams daily or 50100 milligrams three times daily. They were treated with 200 mg of Pycnogenol daily or with placebo. 5 6 However, evidence is conflictingother studies have shown no effect on the same measures. Pycnogenol can help control blood pressure, which helps improve overall heart health. Pycnogenol has been shown to help relieve the pain associated with osteoarthritis by keeping blood chemicals from attacking the cartilage. 2. In a study of 61 ADHD children, pycnogenol reduced hyperactivity, improved attention, and motorics after 1 month. 1) Encourages Healthy Blood Pressure. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Note that the numbers in parentheses (1, 2, etc.) The extract has been widely studied for the past 40 . Pycnogenol lotions applied postirradiation reduced this immunosuppression to 22% (0.05% Pycnogenol) and 13% (0.1% Pycnogenol). Debra Rose Wilson, PhD, MSN, RN, IBCLC, AHN-BC, CHT. A randomized placebo-controlled trial of 60 children with mild-to-moderate asthma found that those who took Pycnogenol may be able to reduce or discontinue their use of rescue inhalers more often than the placebo group [15]. Additionally, athletes have endured less cramping and muscle pain when using the extract. New research has shown promising results for those dealing with erectile dysfunction (ED) and diabetes. Luckily, the Native Americans told them about a tea prepared from the bark of a certain tree, which miraculously led to complete recovery. For children with ADHD, research suggests that symptoms start to return after about a month without taking maritime pine, so taking periodic breaks shouldnt make it any less effective. As a skin powder, however, you can use it safely for up to six weeks. In a study of 33 people with severe osteoarthritis, pycnogenol (200 mg/day) reduced inflammatory markers after 3 weeks. The specific tree from which the bark is extracted is called a maritime pine. editor, The Gale Encyclopedia of Alternative Medicine, third edition, 2009. (8). But did you know that pine bark extract, like pine oil, is one of natures super antioxidants? A 2004 animal study also found that applying a gel containing pine bark extract sped up the wound-healing process. Some of the top lutein-rich foods to include in your diet are dark leafy greens like spinach and kale, broccoli . However, in all the above studies insulin levels did not change. Although the preliminary studies show many health benefits with the use of Pycnogenol, future larger and better studies are needed. Discover what the research says about elimination diets, foods to eat, and more. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. For improving exercise capacity in athletes: 200 milligrams daily. As noted, aspirin can cause severe gastrointestinal issues. In patients with chronic venous insufficiency, the number of muscle cramps decreased from 6.3 to 2.6; in athletes from 8.6 to 2.4. Enzogenol also may reduce mental fatigue and sleep problems [82]. In a study of 76 people with allergic asthma, Pycnogenol (100 mg/day) added to conventional corticosteroid inhalers for 6 months helped 55% of them reduce inhaler use frequency and dosage. It had the best results when combined with compression stockings, but worked just as well alone [28]. Studies have found that nattokinase thins the blood and dissolves accumulated solids in it. Purity and potency of Pycnogenolare continuously monitored . The Best Supplements for Healthy Digestion, How to Get the Protective Power of Vitamin K. According to some researchers, when you take Pycnogenol [8]: Research suggests that Pycnogenol may protect cells in the body against oxidative stress. Not bad. With time, the participants were able to handle more UV radiation without experiencing skin damage [63]. Benefits, Nutrition, Uses & How It Compares vs. Blackberries. Pycnogenol completely normalized function. Although these may still be high quality, the active compounds are more likely to vary.